Exploring of peptides with affinity to HER2 from random peptide libraries using radioisotope; Random hexapeptide libraries with fixed amino acid sequence at 1 and 2 positions

Sasaki, Ichiro; Hanaoka, Hirofumi*; Yamada, Keiichi*; Watanabe, Shigeki; Sugo, Yumi; Ohshima, Yasuhiro; Suzuki, Hiroyuki; Ishioka, Noriko

Peptide Science 2014, p.257 - 260, 2015/03

Basic study of the chemical forms and radiolabeling reaction of At-211 for targeted tumor radiotherapy

Suzuki, Hiroyuki; Hashimoto, Kazuyuki; Nishinaka, Ichiro; Watanabe, Shigeki; Sasaki, Ichiro; Ishioka, Noriko

no journal, , 

no abstracts in English

Production and utilization of astatine radioisotopes using Li ion beams

Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Amano, Ryohei*; Maeda, Eita*; Taniguchi, Takumi*; Murakami, Kento*; Watanabe, Shigeki; Suzuki, Hiroyuki; Ishioka, Noriko; et al.

no journal, , 

In general, an -emitter At which is a prospective candidate for utilization in targeted alpha radiotherapy is produced through the Bi(He, 2n)At reaction. In contrast, our project is focusing on the production in the Bi(Li, 5n)Rn reaction. This enables us to supply At in a Rn/At generator system. The daughter At (7.2 h half-life) is extracted from the parent Rn (14h), expanding time-frame for transportation and use of At. To use astatine and iodine radioisotopes in our project, the excitation functions of Bi(Li, xn)Rn, Pb(Li, xn)At and Sn(Li, xn)I reactions have been measured. In addition to that, separation techniques have been developed. We report not only on the production and separation of astatine and iodine radioisotopes in the reactions but also on the utilization of those radioisotopes.

Development of 2-[At]astato--methyl-L-phenylalanine (2-AAMP) as a novel radiopharmaceutical for internal radiotherapy

Ohshima, Yasuhiro; Suzuki, Hiroyuki*; Hanaoka, Hirofumi*; Watanabe, Shigeki; Watanabe, Satoshi; Watanabe, Naoyuki*; Tsushima, Yoshito*; Endo, Keigo*; Arano, Yasushi*; Ishioka, Noriko

no journal, , 

Synthesis and evaluation of At labeled -methyl-L-phenylalanine

Suzuki, Hiroyuki*; Ohshima, Yasuhiro; Hanaoka, Hirofumi*; Watanabe, Shigeki; Watanabe, Satoshi; Sasaki, Ichiro; Sakashita, Tetsuya; Arano, Yasushi*; Ishioka, Noriko

no journal, , 

no abstracts in English