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面川 真里奈*; 木村 寛之*; 初川 雄一*; 河嶋 秀和*; 塚田 和明; 屋木 祐介*; 内藤 行基*; 安井 裕之*
Bioorganic & Medicinal Chemistry, 97, p.117557_1 - 117557_6, 2024/01
被引用回数:0 パーセンタイル:0.01(Biochemistry & Molecular Biology)Pt was produced via the (n,2n) reaction induced by accelerator neutrons. [Pt]FGC-Pt was obtained through the accelerator neutron irradiation of FGC-Pt and KPtCl. Highly purified [Pt]FGC-Pt was obtained using the latter method, which suggests that the synthetic method using a Pt-labeled platinum reagent is suitable for the radioactivation of platinum complexes. We also investigated whether a significant correlation existed between the biodistribution of FGC-Pt and [Pt]FGC-Pt in healthy mice 24 h after tail vein administration. These results suggest that Pt-labeled compounds, synthesized using radioactive platinum reagents, can be used to confirm the biodistribution of platinum compounds. Our study on the biodistribution of [Pt]FGC-Pt is expected to contribute to the development of novel platinum-based drugs in the future.
宮本 泰明; 山口 大美; 林 和夫*; 田中 元史*; 安井 裕之*; 野田 悦夫*
no journal, ,
ウラン汚染廃棄物の放射能を効率よく測定する方法である線による電離で発生したイオンを空気流に載せて輸送,捕集し測定するという電離空気輸送型計測について、生成したイオンの再結合係数の相対湿度に対する依存性を測定した。