Polyelectrolyte-protein synergism; pH-responsive polyelectrolyte/insulin complexes as versatile carriers for targeted protein and drug delivery

Murmiliuk, A.*; Iwase, Hiroki*; Kang, J.-J.*; Mohanakumar, S.*; Appavou, M.-S.*; Wood, K.*; Almsy, L.*; Len, A.*; Schwrzer, K.*; Allgaier, J.*; et al.

Journal of Colloid and Interface Science, 665, p.801 - 813, 2024/07

https://doi.org/10.1016/j.jcis.2024.03.156

The complexity of protein structure limits our ability to predict and tune the properties of the formed nanoparticles. The goal of our research is to elucidate the key triggers of the morphological transition in protein/PE complexes, evaluate their encapsulation efficacy, and assess particle stability by the systematic study of complexes formed by block copolymers with proteins and ionic drugs. We demonstrated that copolymers consisting of PE and neutral hydrophilic block co-assemble with insulin at pH values close to the protein isoelectric point. The insulin arrangement within the particle is controlled by electrostatic forces between protein molecules, and the morphology of the formed particles can be tuned by varying pH and ionic strength.

Development of wide range photon detection system for muonic X-ray spectroscopy

Mizuno, Rurie*; Niikura, Megumi*; Saito, Takeshi*; Matsuzaki, Teiichiro*; Sakurai, Hiroyoshi*; Amato, A.*; Asari, Shunsuke*; Biswas, S.*; Chiu, I.-H. ; Gianluca, J.*; et al.

Nuclear Instruments and Methods in Physics Research A, 1060, p.169029_1 - 169029_14, 2024/03

https://doi.org/10.1016/j.nima.2023.169029

Predictive and inverse modeling of a radionuclide diffusion experiment in crystalline rock at ONKALO (Finland)

Soler, J. M.*; Keklinen, P.*; Pulkkanen, V.-M.*; Moreno, L.*; Iraola, A.*; Trinchero, P.*; Hokr, M.*; ha, J.*; Havlov, V.*; Trpkoov, D.*; et al.

Nuclear Technology, 209(11), p.1765 - 1784, 2023/11

https://doi.org/10.1080/00295450.2023.2209234

Intruder configurations in Ne at the transition into the island of inversion; Detailed structure study of Ne

Wang, H.*; Yasuda, Masahiro*; Kondo, Yosuke*; Nakamura, Takashi*; Tostevin, J. A.*; Ogata, Kazuyuki*; Otsuka, Takaharu*; Poves, A.*; Shimizu, Noritaka*; Yoshida, Kazuki; et al.

Physics Letters B, 843, p.138038_1 - 138038_9, 2023/08

https://doi.org/10.1016/j.physletb.2023.138038

Detailed -ray spectroscopy of the exotic neon isotope Ne has been performed using the one-neutron removal reaction from Ne. Based on an analysis of parallel momentum distributions, a level scheme with spin-parity assignments has been constructed for Ne and the negative-parity states are identified for the first time. The measured partial cross sections and momentum distributions reveal a significant intruder p-wave strength providing evidence of the breakdown of the N = 20 and N = 28 shell gaps. Only a weak, possible f-wave strength was observed to bound final states. Large-scale shell-model calculations with different effective interactions do not reproduce the large p-wave and small f-wave strength observed experimentally, indicating an ongoing challenge for a complete theoretical description of the transition into the island of inversion along the Ne isotopic chain.

Design and actual performance of J-PARC 3 GeV rapid cycling synchrotron for high-intensity operation

Yamamoto, Kazami; Kinsho, Michikazu; Hayashi, Naoki; Saha, P. K.; Tamura, Fumihiko; Yamamoto, Masanobu; Tani, Norio; Takayanagi, Tomohiro; Kamiya, Junichiro; Shobuda, Yoshihiro; et al.

Journal of Nuclear Science and Technology, 59(9), p.1174 - 1205, 2022/09

https://doi.org/10.1080/00223131.2022.2038301

In the Japan Proton Accelerator Research Complex, the purpose of the 3 GeV rapid cycling synchrotron (RCS) is to accelerate a 1 MW, high-intensity proton beam. To achieve beam operation at a repetition rate of 25 Hz at high intensities, the RCS was elaborately designed. After starting the RCS operation, we carefully verified the validity of its design and made certain improvements to establish a reliable operation at higher power as possible. Consequently, we demonstrated beam operation at a high power, namely, 1 MW. We then summarized the design, actual performance, and improvements of the RCS to achieve a 1 MW beam.

Impact of post-nitridation annealing in CO ambient on threshold voltage stability in 4H-SiC metal-oxide-semiconductor field-effect transistors

Hosoi, Takuji*; Osako, Momoe*; Moges, K.*; Ito, Koji*; Kimoto, Tsunenobu*; Sometani, Mitsuru*; Okamoto, Mitsuo*; Yoshigoe, Akitaka; Shimura, Takayoshi*; Watanabe, Heiji*

Applied Physics Express, 15(6), p.061003_1 - 061003_5, 2022/06

https://doi.org/10.35848/1882-0786/ac6f42

The combination of NO annealing and subsequent post-nitridation annealing (PNA) in CO ambient for SiO/SiC structures has been demonstrated to be effective in obtaining both high channel mobility and superior threshold voltage stability in SiC-based metal-oxide-semiconductor field-effect transistors (MOSFETs). N atoms on the SiO side of the SiO/SiC interface incorporated by NO annealing, which are plausible cause of charge trapping sites, could be selectively removed by CO-PNA at 1300C without oxidizing the SiC. CO-PNA was also effective in compensating oxygen vacancies in SiO, resulting high immunity against both positive and negative bias-temperature stresses.

Estimate of economic impact of atmospheric radiation storm associated with solar energetic particle events on aircraft operations

Saito, Susumu*; Wickramasinghe, N. K.*; Sato, Tatsuhiko; Shiota, Daiko*

Earth, Planets and Space (Internet), 73(1), p.57_1 - 57_10, 2021/12

https://doi.org/10.1186/s40623-021-01377-5

By using an flight trajectory generation algorithm and the global effective dose rate (EDR) distribution calculated WASAVIES, the economic impacts of SEP events on aircraft operation, namely the flight path length, flight time, and fuel consumption, are estimated. The flight path length, flight time, and fuel consumption for a flight route from New York, US to Tokyo, Japan are estimated with constraints in flight routes to avoid the hazard of radiation and compared with those of the reference case without the SEP effects. Setting more flexible constraints in the flight route and generating optimal flight trajectories with minimal economic impacts by fully utilizing the global EDR distribution is the next step.

The Fe(n,)Fe cross section from the surrogate ratio method and its effect on the Fe nucleosynthesis

Yan, S. Q.*; Li, X. Y.*; Nishio, Katsuhisa; Lugaro, M.*; Li, Z. H.*; Makii, Hiroyuki; Pignatari, M.*; Wang, Y. B.*; Orlandi, R.; Hirose, Kentaro; et al.

Astrophysical Journal, 919(2), p.84_1 - 84_7, 2021/10

https://doi.org/10.3847/1538-4357/ac12ce

Evaluation report of Task 9B based on comparisons and analyses of modelling results for the sp HRL LTDE-SD experiments

Soler, J. M.*; Meng, S.*; Moreno, L.*; Neretnieks, I.*; Liu, L.*; Keklinen, P.*; Hokr, M.*; ha, J.*; Vetenk, A.*; Reimitz, D.*; et al.

SKB TR-20-17, 71 Pages, 2021/07

Task 9B of the SKB Task Force on Modelling of Groundwater Flow and Transport of Solutes in fractured rock focused on the modelling of experimental results from the LTDE-SD in situ tracer test performed at the sp Hard Rock Laboratory in Sweden. Ten different modelling teams provided results for this exercise, using different concepts and codes. Three main types of modelling approaches were used: (1) analytical solutions to the transport-retention equations, (2) continuum-porous-medium numerical models, and (3) microstructure-based models accounting for small-scale heterogeneity (i.e. mineral grains and microfracture distributions). The modelling by the different teams allowed the comparison of many different model concepts, especially in terms of potential zonations of rock properties (porosity, diffusion, sorption), such as the presence of a disturbed zone at the rock and fracture surface, the potential effects of micro- and cm-scale fractures.

Quasifree neutron knockout reaction reveals a small -Orbital component in the Borromean nucleus B

Yang, Z. H.*; Kubota, Yuki*; Corsi, A.*; Yoshida, Kazuki; Sun, X.-X.*; Li, J. G.*; Kimura, Masaaki*; Michel, N.*; Ogata, Kazuyuki*; Yuan, C. X.*; et al.

Physical Review Letters, 126(8), p.082501_1 - 082501_8, 2021/02

AA2020-0819.pdf:1.29MB

https://doi.org/10.1103/PhysRevLett.126.082501

A quasifree (,) experiment was performed to study the structure of the Borromean nucleus B, which had long been considered to have a neutron halo. By analyzing the momentum distributions and exclusive cross sections, we obtained the spectroscopic factors for and orbitals, and a surprisingly small percentage of 9(2)% was determined for . Our finding of such a small component and the halo features reported in prior experiments can be explained by the deformed relativistic Hartree-Bogoliubov theory in continuum, revealing a definite but not dominant neutron halo in B. The present work gives the smallest - or -orbital component among known nuclei exhibiting halo features and implies that the dominant occupation of or orbitals is not a prerequisite for the occurrence of a neutron halo.