Re complexes with aminomethylenephosphonate on hydroxyapatiteHashimoto, Kazuyuki; Matsuoka, Hiromitsu; Izumo, Mishiroku
The radioactive rhenium complexes with phosphonate-containing ligands are good bone seeking compounds, and have been developed for the palliative treatment of metastatic bone pain. In this paper, we describe the adsorption properties of newly developed Re complexes with aminomethylenephosphonate (Re-EDTMP, EDBMP and NTMP) on hydroxyapatite, which is the major constituent of the hard tissues of bone. The influence of the shaking time, pH and the ionic strength on the adsorption was investigated. The adsorption of Re complexes was strongly affected by pH and ionic strength in a solution. The adsorption coefficient increased with decreasing pH and ionic strength. These observations suggest that one of the causes of the adsorption of Re-amp is considered the electrostatic forces between the negative 
Re-amp complex and the positive HAP surface. The adsorption affinity of the Re-amp complex for HAP increased in the order Re-EDBMP
Re-NTMPRe-EDTMP.
Language |
: | English |
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Volume |
: | 2 |
Number |
: | 1-2 |
Pages |
: | p.5 - 9 |
Publication Year/Month |
: | 2001/12 |
Paper URL |
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Keywords |
: | Re-188; EDTMP; ヒドロキシアパタイト; 吸着挙動; 骨集積 |
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