• help
  • PC | SP
  • JP | EN
          
Refine your search：     
Report No.
 - 
Clear All
Return to the previous page

A Model for the structure of the ${it Escherichia coli}$ SOS-regulated UmuD$$_{2}$$ protein

Sutton, M. D.*; Guzzo, A.*; Narumi, Issei; Costanzo, M.*; Altenbach, C.*; Ferentz, A. E.*; Hubbell, W. L.*; Walker, G. C.*

UmuD$$_{2}$$ protein is a regulatory subunit of ${it Escherichia coli}$ DNA polymerase V. This protein forms a complex with UmuC protein, a catalytic subunit of DNA polymerase V, and plays a important role in error-prone translesion DNA synthesis, which serves as the mechanistic basis for most DNA-damaging agent and UV light mutagenesis. In this paper, based on the results of a combination of experimental studies, we have developed a refined model for the structure of the UmuD$$_{2}$$ homodimer. Implications of the structural change of UmuD$$_{2}$$ protein with respect to its roles in managing the action of DNA polymease V are discussed.

Language

 :

English

Journal

 :

DNA Repair

Volume

 :

1

Number

 :

1

Pages

 :

p.77 - 93

Publication Year/Month

 :

2002/01

Meeting title

 :

Held date

 :

Location (city)

 :

Location (country)

 :

Patent information

 :

PDF

 :


Paper URL

 :

DOI for research data

 :

Keywords

 :

UmuD Protein; SOS-response; ESR Spectroscopy; DNA Polymerase V; Protein Structure Model

Research Facility

 :

Press Release

 :

Article of JAEA R&D Review

 :

Cooperating Institute

 :

Accesses

 :

- Accesses

InCites™

 :

Altmetrics

 :

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.

Return to the previous page