Development of Ir radiation sources for intravascular irradiation

Kogure, Hiroto; Sorita, Takami; Iwamoto, Seikichi; Nagata, Yasushi*; Hiraoka, Masahiro*; Iwata, Kazuro*; Kawauchi, Yukimasa*; Suzuki, Kazutoshi*

Intravascular brachytherapy is a novel therapy for preventing the restenosis of coronary artery by use of low-dose irradiation. JAERI and Kyoto University have been developing Ir radiation sources by the cooperative research project entitled as "The research on safety and effectiveness of the intravascular brachytherapy for preventing restenosis of the coronary artery disease" since 1998. The radiation source was introduced into the stenosis through a catheter (a guide-tube to insert directly into vascular) to irradiate the diseased part. Ten Ir seed sources (0.4 mm 2.5 mm) were positioned between nylon spacers (0.3 mm 1.0 mm) in a flexible covering tube and the tube was plugged with a core-wire; the tube was shrunk to fix the inside materials and the size is 0.46 mm in diameter and 3 m in length. The physically optimal design was determined to insert the radiation source easily into vascular and to get the dose uniformity in the diseased part. The production method of the radiation source, which is practical to use in the clinics was also established.