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Report No.

Computational simulation on DNA damage induction and repair

Saito, Kimiaki  

DNA is regarded as the major cellular target in biological radiation effects, and DNA damages could cause biological consequences, if they are not properly repaired. The DNA damage induction and repair have been investigated using computational simulation with precise models at a molecular level. Concerning the DNA damage induction, DNA damage induction are simulated using a Monte Carlo method. Especially, in this crossover research project period, the simulation codes have been developed for high-LET radiation So far, it has been confirmed that the energy deposition processes can be properly simulated by the developed codes. In the DNA repair process, the interaction mechanisms of damaged DNA with repair enzymes have been studied using a Molecular Dynamics simulation. In this crossover research period, the study is focused on the complex damages considered to be difficult to repair. These results will be summarized in the presentation.



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