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Short-lived radicals induced in DNA-bases by oxygen and nitrogen K-shell photoexciation

Yokoya, Akinari; Fujii, Kentaro; Akamatsu, Ken; Ukai, Masatoshi*

In order to obtain detailed insights into the physicochemical mechanism of DNA damage induction by oxygen and nitrogen K-shell photoexcitation, short-lived radicals induced in DNA-bases, adenine and guanine, were measured by applying an electroparamagnetic resonance (EPR) spectrometer at the SPring-8 soft X-ray beamline, BL23SU. The samples were prepared as an evaporated thin film in a vacuum chamber. Experimental evidence of the effect of water vapor on the yields of the base radicals will be discussed.

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