Bystander killing of human lung cancer cells by heavy charged particle irradiation

Harada, Kosaku*; Nonaka, Tetsuo*; Hamada, Nobuyuki*; Funayama, Tomoo; Sakurai, Hideyuki*; Sakashita, Tetsuya; Wada, Seiichi*; Kawamura, Hidemasa*; Hasegawa, Masatoshi*; Kobayashi, Yasuhiko; Nakano, Takashi*

We have here examined clonogenic survival of confluent human lung cancer A549 cells exposed to X-rays or 220 MeV 12C $^{5+}$ charged particles. Targeted exposure of 0.001-0.005 % of cells within the confluent population were resulted in 8-15 % reduction of surviving fraction, suggesting that the induced bystander responses are involved in mechanism of cell death by heavy particles.

Language	:	Japanese
Journal	:	JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005
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Pages	:	P. 102
Publication Year/Month	:	2007/02
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Paper URL	:	https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2006-042.pdf
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Keywords	:	no keyword
Research Facility	:	TIARA(イオン照射研究施設)
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Cooperating Institute	:	群馬大学

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Registration No. : AA20070035
JAEA Abstracts No. :
Paper Submission No. : 2393

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