Refine your search�ソスF     
Report No.
 - 

Production of $$^{64}$$Cu as a biotracer and applications to in vivo imaging of $$^{64}$$Cu in a plant

Watanabe, Shigeki; Ishioka, Noriko; Katabuchi, Tatsuya*; Watanabe, Satoshi; Suzui, Nobuo; Ishii, Satomi; Matsuhashi, Shimpei

Positron emitter, $$^{64}$$Cu has been used in medical applications with positron emission tomography (PET). We have developed a novel method in $$^{64}$$Cu production to obtain $$^{64}$$Cu-labelled antibodies as a PET reagent. On the other hand, $$^{64}$$Cu can be used for in vivo imaging of copper in a living plant by positron emitting tracer imaging system (PETIS). Production of $$^{64}$$Cu was carried out via the $$^{64}$$Ni(p,n)$$^{64}$$Cu nuclear reaction. The produced $$^{64}$$Cu (330 MBq) was purified by an ion-exchange method from the irradiated $$^{64}$$NiO target. The $$^{64}$$Cu was obtained with high yield (89%) and high radionuclidic-purity $$^{64}$$Cu ($$>$$ 99%). The $$^{64}$$NiO was recovered in good yield ($$>$$ 99%). The $$^{64}$$Cu was added to a plant (soybean) for an imaging experiment and the movement of $$^{64}$$Cu was visualized by the PETIS. This result shows that $$^{64}$$Cu can be applied as a useful tracer for not only medical applications and also plant physiological studies.

Accesses

:

- Accesses

InCites™

:

Altmetrics

:

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.