Production of radioisotopes for nuclear medicine using ion beam technology and its utilization for both therapeutic and diagnostic application in cancer

Iida, Yasuhiko*; Hanaoka, Hirofumi*; Katabuchi, Tatsuya*; Watanabe, Satoshi; Ishioka, Noriko; Matsuhashi, Shimpei; Oriuchi, Noboru*; Higuchi, Tetsuya*; Miyakubo, Mitsuyuki*; Endo, Keigo*

Radioimmunotherapy (RIT) becomes one of the most promising treatments for cancer therapy. Recently, because various radioisotopes are being used for RIT, the efficient tailor-made therapy is thought to be possible. The high energy -particle-emitter, such as Y (2.28 MeV), seems particularly well suited for the treatment of relatively large tumor masses, but the middle energy -particles, such as Cu (0.18-0.58 MeV), may have an advantage in treating small lesions. In this study, we prepared Cu and evaluated its potential of application for RIT in tumor bearing mice. Our results of tumor localization studies show that Cu was expected to be suitable for RIT.