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A Study on antioxidative property of edaravone derivatives by pulse radiolysis

Hata, Kuniki ; Katsumura, Yosuke; Lin, M.; Muroya, Yusa*; Fu, H.*; Kudo, Hisaaki*; Nakagawa, Keiichi*; Nakagawa, Hidehiko*

The reactivity of edaravone with some oxidative radicals ($$^{.}$$OH, N$$_{3}$$$$^{.}$$, Br$$_{2}$$$$^{.-}$$, SO$$_{4}$$$$^{.-}$$, CClO$$_{3}$$O$$_{2}$$$$^{.}$$) has been measured by pulse radiolysis. The reaction product of edaravone with $$^{.}$$OH was different from those with other radicals. The rate constants of edaravone derivatives with $$^{.}$$OH have also been determined by both direct measurement and a competition method using CO$$_{3}$$$$^{2-}$$ and DMPO as competitors.



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