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Estimation of DNA damage spectrum induced by heavy ions by simulation

Watanabe, Ritsuko; Sato, Osamu*; Kubota, Asako*; Funabiki, Jun*; Saito, Kimiaki  

The purpose of this study is to estimate the yields and the configuration of DNA damages as well as the spatial distribution of the damages along to the tracks of heavy ions using the Monte Carlo simulation. A new Monte Carlo track structure code for any kind of ions from hydrogen to uranium has been developed and applied for simulation of the induction process of DNA damage. Induction of strand breaks and base damages were simulated with direct and the radical generation and diffusion using Monte Carlo methods for atomistic model of DNA. In our presentation, the framework of the developed track code for ions, OH radical yields, and the calculated DNA damage spectrum for selected types of ions for different energies will be shown and discussed by comparison with available experimental data.

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