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Report No.
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Bystander effect studies using heavy-ion microbeam at JAEA-Takasaki

Kobayashi, Yasuhiko; Funayama, Tomoo; Sakashita, Tetsuya; Furusawa, Yoshiya*; Shao, C.*; Hamada, Nobuyuki*; Wada, Seiichi*; Yokota, Yuichiro; Kakizaki, Takehiko*; Fukamoto, Kana; Suzuki, Michiyo; Kataoka, Keiko*; Sora, Sakura

We have established a single cell irradiation system, which allows selected cells to be individually hit with defined number of heavy charged particles, using a collimated heavy-ion microbeam apparatus at JAEA-Takasaki. This system has been developed to study radiobiological processes in hit cells and bystander cells exposed to low dose and low dose-rate high-LET radiations, in ways that cannot be achieved using conventional broad-field exposures. Using this system, we have demonstrated heavy-ion induced bystander effects on Chinese hamster ovary cells and normal human foreskin fibroblast AG01522 cells. The outlines of these direct investigation of cell-to-cell communications will be introduced, and the current status of the development of focused heavy-ion microbeam from AVF cyclotron at JAEA-Takasaki will also be discussed.

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