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What are the mediators of bystander response induced by irradiation of argon particles?

アルゴンイオン照射で誘発されるバイスタンダー応答の媒介因子は何か?

松本 英樹*; 冨田 雅典*; 大塚 健介*; 舟山 知夫; 小林 泰彦

Matsumoto, Hideki*; Tomita, Masanori*; Otsuka, Kensuke*; Funayama, Tomoo; Kobayashi, Yasuhiko

The radioadaptive response, radiation-induced bystander responses, low-dose radio-hypersensitivity, and genomic instability are specifically observed in response to low dose/low dose-rate radiation, and the mechanisms underlying these responses often involve biochemical/molecular signals that respond to targeted and non-targeted events. However, mechanisms of these phenomena are not fully known. To elucidate the mechanisms of radiation-induced bystander responses, we analyzed the formation of $$gamma$$H2AX and pNBS1 foci after irradiation of a targeted cell with 460 MeV $$^{40}$$Ar microbeams. We found that the foci of $$gamma$$H2AX and pNBS1 were formed in the unirradiated cells in the colony including the targeted cell 6 h after the irradiation and that this formation of these foci was almost completely suppressed by the addition of DMSO or Lindane. Also we found that the foci of $$gamma$$H2AX and pNBS1 were formed in the unirradiated cells in the colonies not including the targeted cell 6 h after irradiation and that this formation of the foci was almost completely suppressed by the addition of aminoguanidine or c-PTIO. Our findings strongly suggested that ROS and NO may be actually initiators/mediators for evoking radiation-induced bystander responses.

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