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Report No.
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Structure determination of human cytokines and extracellular domains of receptors

Tamada, Taro; Honjo, Eijiro; Arai, Shigeki; Kuroki, Ryota

The ligand-receptor interaction in the extracellular environment is essential for signal transduction of biological processes. We have focused on the structure/function relationships of these proteins. Granulocyte colony-stimulating factor (GCSF) has become an important cytokine for medical treatment of patients suffering from granulopoenia through regulating the maturation, proliferation, and differentiation of the precursor cells of neutrophilic granulocytes. We determined a crystal structure of the signaling complex between human GCSF and a ligand binding region of GCSF receptor (GCSF-R). We also determined additional structures of human cytokines and extracellular regions of cytokine receptors, where the complexation with an antibody fragment (Fab) was used for crystallization and structure determination.

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