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Development of an apparatus to concentrate $$^{188}$$Re solutions by a multi column system for cancer therapeutic experiments

Hashimoto, Kazuyuki; Motoishi, Shoji*; Saeki, Hideya*; Sorita, Takami; Matsuoka, Hiromitsu

Rhenium-188 is a useful generator-produced radioisotope for therapeutic applications because of their energetic beta particles and $$gamma$$ rays suitable for imaging. Because the $$^{188}$$W parent is obtained in a relatively low specific activity from the irradiation of enriched $$^{186}$$W in a reactor, relatively large volumes of normal saline are required to elute the $$^{188}$$Re from alumina based $$^{188}$$W/$$^{188}$$Re generators. In this study, a simple apparatus for effective concentrations of 188Re solutions from alumina-based $$^{188}$$W/$$^{188}$$Re generators was developed by a tandem cation-anion column system. Concentration ratios greater than 50:1 can be achieved with this apparatus.

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