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Synthesis and stability of [$$^{77}$$Br]-m-Bromobenzylguanidine ($$^{77}$$Br-MBBG)

Watanabe, Shigeki; Ishioka, Noriko; Liang, J. X.; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Endo, Keigo*

$$^{76}$$Br (t$$_{1/2}$$ = 16.2 h, $$beta$$$$^{+}$$ = 57%, EC = 43%) has intermediated half-life and may have great potentials as radionuclide for positron emission tomography (PET). We have produced $$^{76}$$Br via the $$^{76}$$Se(p,n)$$^{76}$$Br reaction using Cu$$_{2}$$$$^{76}$$Se target by AVF cyclotron in JAEA, and also have interest in bromine labeled radiopharmaceuticals. Radioiodine labeled m-iodobenzylguanidine (MIBG) such as [$$^{123}$$I]-MIBG have been widely employed for heart function and tumor imaging with SPECT. In contrast, PET is superior in quantitative measurement and $$^{76}$$Br labeled bromobenzylguanidine (MBBG) can be expected to employ as a novel imaging reagent with PET. In this work, we synthesized radioactive Br labeled MBBG using $$^{77}$$Br and evaluated the chemical properties and stability of Br-MBBG.

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