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Synthesis and stability of $$^{76}$$Br-${it m}$-bromobenzylgianidine ($$^{76}$$Br-MBBG)

Watanabe, Shigeki; Hanaoka, Hirofumi*; Liang, J. X.; Iida, Yasuhiko*; Endo, Keigo*; Ishioka, Noriko

$$^{76}$$Br (t$$_{1/2}$$ = 16.2 h, $$beta$$$$^{+}$$ = 57%, EC = 43%) has intermediated half-life and may have great potentials as radionuclide for positron emission tomography (PET). We have produced $$^{76}$$Br via the $$^{76}$$Se(p,n)$$^{76}$$Br reaction using Cu$$_{2}$$$$^{76}$$Se target, and also have interest in bromine labeled radiopharmaceuticals. Radioiodine labeled ${it m}$-iodobenzylguanidine (MIBG) such as [$$^{123}$$I] or [$$^{131}$$I]-MIBG have been widely employed for imaging of myocardial function and neuroendcrine tumor with single photon emission computed tomography (SPECT). PET is superior in quantitative measurement to SPECT, thus positron emitter $$^{76}$$Br-labeled MIBG can be expected to employ as a novel imaging reagent for PET. In this study, we synthesized $$^{76}$$Br labeled meta-bromobenzylguanidine ($$^{76}$$Br-MBBG) for tumor imaging by PET to evaluated stability in serum and biodistribution of $$^{76}$$Br-MBBG using normal mice.

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English

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Publication Year/Month

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Meeting title

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4th International COE Symposium on Biomedical Research Using Accelerator Technology

Held date

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2008/11

Location (city)

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Maebashi

Location (country)

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Japan

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Keywords

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no keyword

Research Facility

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TIARA(イオン照射研究施設)

Press Release

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Article of JAEA R&D Review

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Cooperating Institute

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群馬大学

Accesses

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- Accesses

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