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Pulse radiolysis study on reactivity of edaravone derivatives with hydroxyl radical

Hata, Kuniki ; Katsumura, Yosuke; Lin, M.; Muroya, Yusa*; Fu, H.*; Yamashita, Shinichi; Kudo, Hisaaki*; Nakagawa, Keiichi*; Nakagawa, Hidehiko*

Edaravone and its derivatives are good radical scavengers and expected as a potent radioprotector. In this study, their $$^{.}$$OH scavenging reactivity was measured by pulse radiolysis technique, and all derivatives showed high reactivity with $$^{.}$$OH. As a result of measuring rate constants by using competition methods by DMPO, it was shown that there was interaction between derivatives including pyridine ring and DMPO.

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