Nano-particle materials prepared from a synthetic antigenic sequence of enolase

Oku, Hiroyuki*; Yamada, Keiichi*; Kobayashi, Kyoko*; Katakai, Ryoichi*; Ashfaq, M.*; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Endo, Keigo*; Hasegawa, Shin; Maekawa, Yasunari; Yano, Kazuhiko*; Kano, Shigeyuki*; Suzuki, Mamoru*

Malaria is the major cause of mortality and morbidity in the tropical and subtropical regions in the world. Our previous studies have shown that a series of partial peptides of a Plasmodium falciparum enolase have antigenic reactivity against patients' sera. In this paper, we wish to report nano-encapsulation of a synthetic antigen into bioabsorbable polymer particles and their releasing studies in vitro and in vivo.