Yield determination of OH with therapeutic ion beam

Maeyama, Takuya*; Katsumura, Yosuke; Yamashita, Shinichi; Baldacchino, G.*; Taguchi, Mitsumasa; Kimura, Atsushi; Murakami, Takeshi*

Solution of Coumarin-3-carboxylic acid (CCA) has been applied to yield measurement of OH in water radiolysis with carbon ion beams. Production yield of a fluorescent probe, 7OH-CCA, which is a stable product produced after scavenging reaction for OH by CCA, was determined by using HPLC connected to a fluorometer. By using this chemical system, OH yields near the Bragg peak have been measured. Contribution of fragmentations, which are known to be significant near the Bragg peak of high-energy heavy ions, is also discussed by conducting fragmentation simulation with deterministic, semi-empirical and one-dimensional code named HIBRAC.