A Study on the reaction mechanisms of edaravone and its derivatives

Hata, Kuniki ; Katsumura, Yosuke; Lin, M.; Muroya, Yusa*; Yamashita, Shinichi; Fu, H. Y.*; Kudo, Hisaaki*; Nakagawa, Keiichi*; Nakagawa, Hidehiko*

In order to investigate the reaction mechanism of edaravone (3-methyl-1-phenyl-2-pyrazolin- 5-one) with OH, the reactivity of edaravone derivatives which have different substituent from edaravone was observed by pulse radiolysis system. From the experiments, OH-adduct radical formed by the addition of OH to phenyl group has been identified as a main intermediate.