Monte Carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths

Watanabe, Ritsuko; Wada, Seiichi*; Funayama, Tomoo; Kobayashi, Yasuhiko; Saito, Kimiaki  ; Furusawa, Yoshiya*

Microscopic energy deposition pattern in an ion track is thought to affect on the spatial distribution of DNA damage as well as the damage spectrum. In this study, we focus on the intra-track spatial distribution of DNA damage in cellular condition based on the energy deposition pattern for each ion obtained by the detailed Monte Carlo track structure simulation. The estimation was performed for C and Ne ions with similar LET around 440 keV/m. As a result, radial DNA damage distribution shows different pattern for C and Ne ions. That is, DSBs or non-DSB type clustered damage are formed in the limited central area while the isolated damages as SSBs and base lesions are spread in larger area. Such tendency is more clearly shown for Ne ions than C ions. This result shows good agreement with the previously obtained experimental observation at TIARA, which indicates the different types of DNA damage shows different distribution pattern around C and Ne projectiles in cell nuclei.