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Report No.

Grapping with problems in analytical science for radiation damage in DNA; For understanding relationship between radiation-chemical changes in DNA and subsequent biological responses

Akamatsu, Ken

I have been considering how to clarify chemical difference in DNA damage spectrum among radiation qualities. In order to confront the problem, it should be necessary to develop new-conceptual analytical methods for damaged DNA by ionizing radiation. In this report, following to the explanation of overall background of upstream of radiation biology, brief history of the analytical chemistry with problems, a few analytical trials to discover characteristics of radiation qualities are demonstrated. The present efforts against the problems are discovering difference in strand- break termini between high- and low- LET radiation.



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