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Production of no-carrier-added $$^{177}$$Lu for radioimmunotherapy

Watanabe, Satoshi; Hashimoto, Kazuyuki; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko

Lutetium-177 is considered to have potential for application in radioimmunotherapy, because it emits $$beta$$-particles (E$$_{max}$$=498 keV) suitable to penetrate small tumors and its physical half-life of 6.734 days is long enough for $$^{177}$$Lu-labeled antibodies to accumulate to tumor sites. In addition, real time imaging of biodistribution can be done by using the $$^{177}$$Lu, because the energy of $$gamma$$-rays (113 keV and 208 keV) emitted from $$^{177}$$Lu is particularly suitable for imaging by single photon emission computed tomography. We can produce $$^{177}$$Lu by the $$^{176}$$Lu (n,$$gamma$$) $$^{177}$$Lu process and the $$^{176}$$Yb(n,$$gamma$$) $$^{177}$$Yb (T$$_{1/2}$$=1.911 h)$$rightarrow$$$$^{177}$$Lu process. In the field of radioimmunotherapy using labeled monoclonal antibodies, to enhance the effect of therapy, no-carrier-added (nca) $$^{177}$$Lu produced in the $$^{176}$$Yb(n,$$gamma$$) $$^{177}$$Yb (T$$_{1/2}$$=1.911 h) $$rightarrow$$$$^{177}$$Lu process with high specific radioactivity are required. Therefore, in the present paper, production of highly-purified nca $$^{177}$$Lu from macroscopic amounts of the ytterbium target is developed.

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English

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2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)

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2010/12

Location (city)

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Honolulu

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U.S.A.

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no keyword

Research Facility

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RI製造棟  

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JAEA R&D Navigator

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Cooperating Institute

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群馬大学

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