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Oligomeric structure of nucleoside diphosphate kinase from Halomonas sp.593 (HaNDK)

Arai, Shigeki; Yonezawa, Yasushi; Okazaki, Nobuo; Tamada, Taro; Tokunaga, Hiroko*; Ishibashi, Matsujiro*; Tokunaga, Masao*; Kuroki, Ryota

The nucleoside diphosphate kinases (NDKs) are known to have a tetrameric or hexameric oligomer structure formed by association of common dimeric components. We determined the crystal structure of E134A mutant NDK from ${it Halomonas}$ sp. 593 (HaNDK) and found that two kinds of tetrameric assemblies, Type I seen in the ${it Myxococcus}$ NDK tetramer and Type II seen in the ${it E.coli}$ NDK tetramer, appeared in the asymmetric unit. Change in the assembly form may be an effective way for NDK to acquire molecular characteristics suited to various circumstances.

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