Effects of -ray irradiation on locomotory behavior and mechanosensation in

Suzuki, Michiyo; Sakashita, Tetsuya; Kikuchi, Masahiro; Funayama, Tomoo; Yokota, Yuichiro; Hattori, Yuya; Kobayashi, Yasuhiko

We examined effects of -ray and irradiation on the basal slowing response regarding to mechanosensation in - mutants that are deficient in a tyrosine hydroxylase for the synthesis of dopamine, and found that the -induced reduction of the locomotory rate (motility) was not mediated by -. Additionally, the results suggest that bacterial mechanosensation in might be the dominant mechanism regulating locomotory rate, masking the effects of other stimuli such as IR. Furthermore, dose response pattern in locomotory rate of carbon ion-irradiated animals was similar to that of -irradiated animals, it can state that the effects of IR do not depend on LET within the dose we examined. Moreover we showed possibility that HO produced by IR might concern to the IR-induced reduction of locomotory rate.