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Report No.
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Recent activity of neutron diffractometers for biological crystallography at Japan Atomic Energy Agency

Tamada, Taro; Kurihara, Kazuo; Ohara, Takashi   ; Okazaki, Nobuo; Kuroki, Ryota

Neutron crystallography, which is a powerful technique for locating hydrogen atoms, enables us to obtain accurate atomic positions within proteins. Neutron diffraction data can provide information of the location of hydrogen atoms to the structural information determined by X-ray crystallography. There are two neutron diffractometers for biological crystallography (BIX-3 and BIX-4) installed at research reactor (JRR-3) in Japan Atomic Energy Agency (JAEA), which have been contributed to 15 structure analyses of biological macromolecules. Here, we report the recent activities for developments of the neutron diffractometers and the structure analysis of drug-target proteins.

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