Elevated depressive symptoms increase metabolic syndrome prevalence through hypertriglyceridemia in Japanese male workers

うつ症状は日本人男性労働者において高中性脂肪血症を介してメタボリックシンドローム有病率を増加する

亀崎 文彦; 園田 信成*; 尾辻 豊*

Kamezaki, Fumihiko; Sonoda, Shinjo*; Otsuji, Yutaka*

Aim: The aim of this study was to determine whether elevated depressive symptoms are associated with metabolic syndrome and its parameters in Japanese population. Methods: Of 1,386 male workers who were measured variables of the metabolic parameters in their health checkup, 1,186 (44.59.6 years) answered the Zung self-rating depression scale (ZSDS). In this study, metabolic syndrome was defined according to the joint scientific statement proposed by 6 major organizations. Results: Of the 1,186 subjects, 42.1% had elevated depressive symptoms (ZSDS scores 40). The prevalence rate of metabolic syndrome was significantly higher in subjects with elevated depressive symptoms than in those without (13.2% vs 8.9%, p0.05). Of all metabolic parameters, serum levels of triglyceride were significantly higher in subjects with elevated depressive symptoms (124.779.1 mg/dL vs 111.558.4 mg/dL, p0.001), and consequently hypertriglyceridemia (28.9% vs 21.0%, p0.01) was the main component correlated with the between-group difference of metabolic syndrome prevalence. Moreover, depressive symptoms for metabolic syndrome were confusion (OR: 1.46; p0.05) and emptiness (OR: 1.50; p0.05). Conclusion: This study suggested that elevated depressive symptoms might increase metabolic syndrome prevalence through a higher occurrence of hypertriglyceridemia in Japanese male workers.