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Molecular analysis of carbon ion induced mutations in yeast ${it Saccharomyces cerevisiae}$ cells

Shimizu, Kikuo*; Matsuo, Yoichiro*; Izumi, Yoshinobu*; Hase, Yoshihiro; Nozawa, Shigeki; Sakamoto, Ayako; Narumi, Issei

To elucidate the molecular mechanism of mutagenesis caused by ion beam irradiation in yeast, two mutant strains ${it ogg1}$ and ${it msh2}$ which are deficient in mismatch repair mechanisms were used to measure mutation spectra. Several hot spots were found in the ${it ogg1}$ mutant, while mutations in the ${it msh2}$ mutant were distributed evenly for base substitution except one hot spot at position 345. These results suggest that the incorporation of damaged nucleotides was not uniform in yeast cells.

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