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Developing an integrated, laser-driven ion accelerator system for ion beam radiotherapy; Progress and challenges

進展とチャレンジ; イオンビーム放射線治療のための統合レーザー駆動イオン加速器システムの開発

Bolton, P.

Bolton, P.

The primary goal of the Photo-Medical Research Center (PMRC) of the Japan Atomic Energy Agency is developing an integrated, laser-driven ion accelerator system (ILDIAS) prototype for application to laser-driven ion beam radiotherapy (L-IBRT). PMRC pursues all-optical acceleration of protons to high kinetic energy ($$sim$$250 MeV) via intense laser-plasma interaction at the target site. The ILDIAS concept is presented along with some laser and proton beam delivery requirements for radiotherapy. The ILDIAS will necessarily be comprised of several subsystems that include at least: the laser, the target, instrumentation, ion transport optics and the delivery (to the patient). Toward our higher energy goal for L-IBRT we have achieved maximum proton energies near 14 MeV in single shot experiments and also demonstrated repetition-rated (1 Hz) transport of protons with energy up to 3 MeV. At about 2 MeV 5 nanosecond bunches have been transported at a flux level 106 protons/cm$$^{2}$$ with a 5% energy spread. Also for recent cell irradiation studies we transported 20 nanosecond bunches at 2.3 MeV with flux levels of order 107 protons/cm$$^{2}$$ with a 30% energy spread. In this latter case human cancer cells received single bunch doses of 0.2 Gy. Typically we can expect the ILDIAS to produce single bunches of $$sim$$10 nanosecond duration with low duty factors in the range, 10$$^{-7}$$ to 10$$^{-6}$$ for 10 Hz and 100 Hz repetition-rate operation respectively.

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