Preparation and characterization of two cytokine receptor homologues regions comprising the thrombopoietin receptor extra cellular region

Matsumoto, Fumiko; Adachi, Motoyasu; Shimizu, Rumi; Meguro, Mizue; Tamada, Taro; Kato, Takashi; Kuroki, Ryota

Thrombopoietin (TPO) is a glycoprotein hormone produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that fragment into large numbers of platelets. The extracellular domain consists of 450 amino acid residues of thrombopoietin receptor (soluble TPO-R) contains two repeat of cytokine receptor homologous region, CRH-1 and CRH-2. In this work, we prepare CRH-1domein of TPO-R, and we discover that CRH-1 has binding site of TPO.

Language	:	Japanese
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Meeting title	:	第11回日本蛋白質科学会年会
Held date	:	2011/06
Location (city)	:	吹田
Location (country)	:	日本
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Registration No. : BB20110367
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