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The Evaluation DNA radiation damage in BNCT by track structured Monte Carlo simulation code

Kaburagi, Masaaki* ; Watanabe, Ritsuko; Sato, Tatsuhiko  ; Yokoya, Akinari; Pinak, M.; Katsumura, Yosuke*; Uesaka, Mitsuru*

In Boron Neutron Capture Therapy (BNCT) borate-ions selectively accumulated in tumor an following neutron capture reactions emit secondary particles, low-energy alpha particle and lithium ion. These particles deposit their energies in tumor effectively. However, there is not enough experimental data to evaluate BNCT biological effectiveness from clinical and research experiments. In our presentation, we introduce results on the research focused on evaluation of the biological effectiveness of the production of DNA strand breaks during BNCT. DNA strand breaks is evaluated based on the microdosimetric data by using Monte Carlo track simulation code. This presentation shows the results of energy deposition, OH radical yields, and DNA strand break yields in aqueous solution. The simulation results are compared with experimental data. Finally we also plan to conduct DNA strand break simulations under conditions as those in actual treatments.

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