Modelling radiation health effects

Ouchi, Noriyuki

In general, we know that carcinogenesis by low dose radiation will start from DNA damage by ionizing radiation. Then, these very small effects will appear on a cellular scale by accumulation of various intracellular biological responses with spending long time and finally grow to the tumor with clonal expansion of cancer cell. In this review, we mainly focus on cellular level phenomena, i.e., process of the cell carcinogenesis and tumorigenesis. The contents will be as follows; (1) problem overview, (2) review of the biological radiation effects problem, (3) introduction of computational approach of the problem, (4) modeling radiation effects of cellular level, (5) simulation results and analysis (Growth-Curve analysis), (6) Conclusion and remarks.