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Can repair enzymes attach moving chromosomal broken ends?

Ouchi, Noriyuki; Pinak, M.

As one of the measures of radiation effects, dose vs. frequency of DNA strand breaks (at the cellular level) or, frequency of chromosomal aberrations (at the individual level) are commonly used. As we know, dose, DNA strand breaks and chromosomal aberrations are successive events, there are no common understandings for these relations. We have investigated many types of chromosomal dynamics using mathematically modeled whole human chromosome 17. Here, we will report on the relationship between physical properties of dynamics of chromosomal broken ends and concentration speed of typical repair enzymes.

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