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Observation of cleavage in DNA and nucleotides following oxygen $$K$$-shell ionization by measuring X-ray absorption near edge structure

Fujii, Kentaro; Fukuda, Yoshihiro; Yokoya, Akinari

To evaluate DNA damage caused by irradiation with soft X-rays, we measured spectra of the X-ray absorption near edge structure (XANES) of DNA and nucleotide films exposed to monochromatic soft X-rays. Calf Thymus DNA and nucleotides films were used as samples. Spectral changes in XANES around the N $$K$$-shell and O $$K$$-shell were observed as a result of irradiation with 560 eV soft X-rays from beamline BL23SU at SPring-8. The observed spectra show the initiation of the new products and the dissociation of molecular structure of the DNA and nucleotides by the irradiation. Results suggest that the major reactions due to irradiation with soft X-rays are deprotonation of nucleobases and decomposition of furanose rings at DNA deoxyribose sites.

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