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Thermosensitive micelles composed of poly(lactide)-$$g$$-poly(NIPAM-$$co$$-HEMA) graft copolymers

Quynh, T. M.*; Yoneyama, Masaru*; Maki, Yasuyuki*; Nagasawa, Naotsugu; Dobashi, Toshiaki*

Different poly(${it N}$-isopropylacrylamide-${it co}$-hydroxyethyl methacrylate) copolymers [P(NIPAM-${it co}$-HEMA)] were synthesized from ${it N}$-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) monomers by both radical and radiation polymerizations for comparison. PLLA-${it g}$-P(NIPAM-${it co}$-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-${it co}$-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-${it co}$-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.

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