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Cs$$^{+}$$ and Sr$$^{2+}$$ recognition mechanism of halophilic $$beta$$-lactamase

Arai, Shigeki; Yonezawa, Yasushi; Adachi, Motoyasu; Tokunaga, Hiroko*; Ishibashi, Matsujiro*; Tokunaga, Masao*; Kuroki, Ryota

Proteins can distinguish various metal ions. Recently, we succeeded in X-ray crystallographic analysis of the halophilic $$beta$$-Lactamase (HaBLA) derived from ${it Chromohalobacter}$ sp.560 under the existence of Cs+ and Sr2+. Diffraction data at 2.0 ${AA}$ resolution (space group P31, Unit cell a = b =115.9 ${AA}$, c =67.9 ${AA}$, Rmerge 9.6%) was collected. Three Cs$$^{+}$$ and six Sr$$^{2+}$$ metal ion binding sites of HaBLA molecules in the asymmetric unit were identified. This structural information is very useful to create the artificial Cs$$^{+}$$ or Sr$$^{2+}$$ binding site on the protein molecules.

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Japanese

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第12回日本蛋白質科学会年会

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2012/06

Location (city)

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名古屋

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日本

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no keyword

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Press Release

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Article of JAEA R&D Review

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Cooperating Institute

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鹿児島大学

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- Accesses

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