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Lethal effects of different LET radiations in gene disruptant strain of ${it Deinococcus radiodurans}$

デイノコッカス・ラジオデュランス遺伝子破壊株における異なるLET放射線の致死効果

佐藤 勝也; 手島 光平; 小野寺 威文; 鳴海 一成

Sato, Katsuya; Tejima, Kohei; Onodera, Takefumi; Narumi, Issei

In this study, we investigated lethal effects of different LET radiations in ${it recA}$ and ${it pprA}$ gene disruptant strains and determined the relationship between LET and RBE. In both gene disruptant strains, radiosensitivities to four kinds of ion beams ($$^{4}$$He$$^{2+}$$, $$^{12}$$C$$^{6+}$$, $$^{12}$$C$$^{5+}$$ and $$^{20}$$Ne$$^{8+}$$) were almost equal to that of the $$gamma$$ rays. Both gene disruptant strains did not exhibit the dependence of LET on RBE at range of LET from about 0.2 to 441 keV/$$mu$$m. These results indicate that RecA-mediated HR and PprA-mediated NHEJ mechanisms in ${it Deinococcus radiodurans}$ play important roles in repairing the ion beams-induced clustered damage as well as the $$gamma$$ ray-induced damage.

使用言語

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English

掲載資料名

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JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010

巻

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ページ数

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P. 106

発行年月

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2012/01

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no keyword

特許データ

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PDF

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論文URL

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https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2011-043.pdf

研究データの公開先DOI

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使用施設

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TIARA(イオン照射研究施設)

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論文解説記事
(成果普及情報誌)

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- Accesses

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