Innate immune genes including a mucin-like gene, , induced by ionizing radiation in

Kimura, Takafumi*; Takanami, Takako*; Sakashita, Tetsuya; Wada, Seiichi*; Kobayashi, Yasuhiko; Higashitani, Atsushi*

Here, we found that exposure to ionizing radiation (IR) induce certain innate immune response gene of in the intestine. Pre-treatment with IR before seeding on lawn plate, significantly increased survival rate in the nematode. IR induction of gene was highly dependent on the ELT-2 transcription factor and p38 MAPK. Moreover, the insulin/IGF-1 signal pathway works as an enhancer of induction of this gene. Silencing of the gene led to growth retardation after IR irradiation. Finally, we describe the cross-tolerance between the responses to radiation exposure and innate immune system.