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Innate immune genes including a mucin-like gene, ${it mul-1}$, induced by ionizing radiation in ${it Caenorhabditis elegans}$

Kimura, Takafumi*; Takanami, Takako*; Sakashita, Tetsuya; Wada, Seiichi*; Kobayashi, Yasuhiko; Higashitani, Atsushi*

Here, we found that exposure to ionizing radiation (IR) induce certain innate immune response gene of ${it mul-1}$ in the intestine. Pre-treatment with IR before seeding on ${it Pseudomonas aeruginosa}$ lawn plate, significantly increased survival rate in the nematode. IR induction of ${it mul-1}$ gene was highly dependent on the ELT-2 transcription factor and p38 MAPK. Moreover, the insulin/IGF-1 signal pathway works as an enhancer of induction of this gene. Silencing of the ${it mul-1}$ gene led to growth retardation after IR irradiation. Finally, we describe the cross-tolerance between the responses to radiation exposure and innate immune system.

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