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※ 半角英数字
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Synthesis and biological evaluation of radiobrominated compounds for tumor imaging

腫瘍イメージングに向けた放射性臭素化化合物の合成と生物学的評価

渡邉 茂樹

Watanabe, Shigeki

$$^{76}$$Br (half-life = 16.1 h) is an attractive radionuclide for PET imaging, because its half-life is long enough to trace in vivo behavior of biologically active molecule. We have produced $$^{76}$$Br by using an AVF cyclotron at JAEA, and synthesized some radiobrominated compounds, $$^{76}$$Br-MBBG, a PET imaging reagent for norepinephrine transporter expressing tumors, and $$^{76}$$Br-BAMT, an amino acid tracer for imaging of various tumors. Synthesis and biological evaluations of these PET reagents will be reported in the symposium, and recent studies on radiobromination in JAEA will be also discussed.

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