A Role of heavy-ion microbeam for analyzing heavy-ion induced radiation response on cell populations

Funayama, Tomoo; Yokota, Yuichiro; Ikeda, Hiroko; Kobayashi, Yasuhiko

When cells are irradiated with a few Gy of high-LET ions, the heterogeneous mixture comprising nonhit, single-hit, and multihit cells in the same population arise in the cell population and it makes difficult to evaluate the accurate cellular effects of heavy ions. More over, the response of the cell population is modified by bystander response in such situation. Target irradiation of individual cells with heavy-ion microbeam is a useful means for analyze such a complicated situation. In this talk, we will introduce the potential of heavy-ion microbeam system of JAEA-Takasaki, and outline of our research using it.