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Report No.

Time-dependent change of heavy-ion induced bystander response in different cells or same cells

Ikeda, Hiroko; Yokota, Yuichiro; Funayama, Tomoo; Muto, Yasuko; Kanai, Tatsuaki*; Kobayashi, Yasuhiko

The purpose of this research is to comprehend a characteristic phenomenon by comparing bystander responses between different cells and same cells. In our experiments, human lung normal fibroblasts WI-38 line and human lung cancer cells H1299/wt${it p53}$ line were used. Cells were irradiated with carbon-ion broad beams (WI-38:0.13 Gy, H1299/wt${it p53}$:0.5 Gy), then survival rates of bystander cells after 6- or 24-hours co-culture with irradiated cells was calculated using colony formation assay. When we co-cultured irradiated WI-38 with non-irradiated WI-38, it was found that survival rates of WI-38 decreased about 15% after 6-hours and 24-hours co-culture. On the other hand, when we co-cultured irradiated H1299/wt${it p53}$ with non-irradiated WI-38, it was found survival rates of WI-38 increased about 10% after 24-hours co-culture. Consequently, when the kinds of irradiated cells differed, it found out that heavy-ion induced bystander responses change a lot.



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