Structure of enzyme-inhibitor complex determined by neutron crystallography

Tamada, Taro; Adachi, Motoyasu; Kurihara, Kazuo; Kuroki, Ryota

Neutron crystallography enables us to identify the accurate hydrogen positions in proteins, which play important roles in many chemical reactions in living system. Here we show our results of neutron structure determination of enzymes in complex with its inhibitors which corresponds to transition state analogues. Neutron structure analysis elucidated the detail catalytic reaction of each enzyme by direct observation of hydrogen atoms. Furthermore we would like to introduce a new neutron beam line for neutron structural biology planned at MLF in J-PARC.

Language	:	Japanese
Journal	:	Nihon Kessho Gakkai-Shi
Volume	:	55
Number	:	1
Pages	:	p.47 - 51
Publication Year/Month	:	2013/02
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Paper URL	:	https://doi.org/10.5940/jcrsj.55.47
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Keywords	:	no keyword
Research Facility	:	JRR-3M(研究炉3)
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Registration No. : AA20120978
JAEA Abstracts No. : 41000713
Paper Submission No. : 12519

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