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Exploration of the site responsible for the radiation response of the salt chemotaxis learning in ${it C. elegans}$ using heavy-ion microbeam

Sakashita, Tetsuya; Suzuki, Michiyo; Muto, Yasuko*; Hattori, Yuya; Ikeda, Hiroko; Yokota, Yuichiro; Funayama, Tomoo; Hamada, Nobuyuki*; Fukamoto, Kana*; Kobayashi, Yasuhiko

An increasing body of data indicates that ionizing radiation causes learning impairments. To understand the effects of ionizing radiation on the nervous system, we have studied the salt chemotaxis learning in ${it Caenorhabditis elegans}$. We recently found the modulatory effect of $$gamma$$-rays on the salt chemotaxis learning that was manifested as a decrease in chemotaxis. However, we have no direct evidence for the interaction of ionizing radiation with the central neuronal tissue (nerve ring) of the nervous system in ${it C. elegans}$. Localized ionizing irradiation is useful to analyze radiation effects at a cellular or tissue level. Thus, to investigate the effects on the nerve ring, we used the heavy-ion microbeam system installed at the Takasaki Ion accelerators for Advanced Radiation Application of JAEA. In this presentation, we will discuss the preliminary results and a future vision of this study.

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