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Report No.

Calculation of heavy ion-induced DNA damage based on microdosimetric quantities

Watanabe, Ritsuko; Yokoya, Akinari; Hashimoto, Shintaro  ; Sato, Tatsuhiko   

The microscopic distribution of energy deposition is an essential factor to determine the relative biological effectiveness (RBE) of heavy ions. Although the linear energy transfer (LET) is the most generally used parameter for comparison of RBE, microdosimetric quantities as lineal energy (y) are considered to be more suitable parameter, as they reflects the ionization densities in microscopic sites. In this study, we focus on the evaluation of the number of DNA damage in relation to the microdosimetric quantities in the sites of sub-cellular sizes by Monte Carlo simulation. The numbers of double strand breaks (DSB), complex damages were calculated around the several mono-energetic ions. In the presentation, the number of DNA damage induced in the microscopic site correlated with the lineal energy and also the spatial distribution of the damages along the ion trajectories will be shown and discussed in terms of the cell-survival fraction models.



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