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Report No.
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The Development of heavy-ion microbeam systems in JAEA-Takasaki

Funayama, Tomoo; Yokota, Yuichiro; Sakashita, Tetsuya; Suzuki, Michiyo; Ikeda, Hiroko; Kobayashi, Yasuhiko

Target irradiation of individual cells using microbeam is a useful means to investigate the mechanism of heavy-ion radiation action. In JAEA-Takasaki, there are two microbeam systems for biological study: the collimating heavy-ion microbeam system, and the focusing heavy-ion microbeam system. The collimating microbeam system was developed and installed at mid 1990's and has been utilized for various biological studies. To explore the behaviors of the whole cell population after bystander irradiation, an integration of live-cell imaging technology into the cell targeting-and-observation system of the collimating microbeam system is under development. On the other hand, we established a method to irradiate finer heavy-ion microbeam from focusing heavy-ion microbeam system on individual HeLa cells. For rapid and accurate delivery of heavy-ions to the individual cells, a method for targeting cells with scanned beam is under development.

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