Refine your search:     
Report No.

Complexation of lutetium-177 with bifunctional chelators in the presence of competing metals

Watanabe, Satoshi; Hashimoto, Kazuyuki; Ishioka, Noriko

As basic studies of bifunctional chelating agent for $$^{177}$$Lu -labeled antibodies, $$^{177}$$Lu complexation of DOTA and DTPA was investigated by the addition of competing metals, Ca(II), Fe(II) and Zn(II). From comparison of competing metals, the inhibition by competing metals on the $$^{177}$$Lu complexation was in the order of Ca(II)$$<$$Fe(II)$$<$$Zn(II) and Ca(II)$$<$$Zn(II)$$<$$Fe(II) as DOTA and DTPA, respectively. For comparison between DOTA and DTPA, the susceptibility to the inhibition on $$^{177}$$Lu complexation by all the three competing metals was DTPA$$<$$DOTA. Therefore, it was found that DTPA is advantageous for $$^{177}$$Lu complexation compared with DOTA in the presence of Ca(II), Fe(II) and Zn(II), and that the elimination of Fe from $$^{177}$$Lu solution is especially effective because the $$^{177}$$Lu complexation of DTPA is highly inhibited by Fe(II).



- Accesses





[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.