• help
  • PC | SP
  • JP | EN
          
Refine your search：     
Report No.
 - 
Clear All
Return to the previous page

Deterministic parsing model of the compound biological effectiveness (CBE) factor for intracellular $$^{10}$$boron distribution in boron neutron capture therapy

Ishiyama, Shintaro

Deterministic parsing model of Compound Biological Effectiveness (CBE) in BPA-mediated BNCT was proposed for intra-organ $$^{10}$$B distribution. In defining the biological effects of the $$^{10}$$B($$n$$,$$alpha$$)$$^{7}$$Li neutron capture reaction, CBE factor model is expressed; CBE = CBE$$_{0}$$ ($$r_{0}$$ $$<$$ $$r$$ or $$N$$ $$<$$ $$N_{rm th}$$) and CBE = CBE$$_{0}$$ + $$F$$[1-($$N$$/$$N_{rm th}$$)(-2/3)][1-($$N$$/$$N_{rm th}$$)(-1/3)] ($$r_{0}$$ $$>$$ $$r$$ or $$N$$$$>$$$$N_{rm th}$$) Where $$r$$ and $$r_{0}$$ are distance between boron atoms and $$alpha$$ range, $$N$$ and $$N_{rm th}$$ are boron concentration and threshold of $$^{10}$$B concentration in tissues and tumour, CBE$$_{0}$$ and $$F$$ are obtained as 0.5 and 8 for normal tissues and for tumour, respectively. $$N$$ and $$N_{rm th}$$ are evaluated the bio-distribution of $$^{10}$$B in normal tissues and tumour after injection and the CBE factor for normal tissues and tumor approximately within + 0.12 to -0.54% high accuracy.

Language

 :

English

Journal

 :

Journal of Cancer Therapy

Volume

 :

5

Number

 :

14

Pages

 :

p.1388 - 1398

Publication Year/Month

 :

2014/12

Meeting title

 :

Held date

 :

Location (city)

 :

Location (country)

 :

Patent information

 :

PDF

 :


Paper URL

 :

https://doi.org/10.4236/jct.2014.514140

DOI for research data

 :

Keywords

 :

no keyword

Research Facility

 :

Press Release

 :

Article of JAEA R&D Review

 :

Cooperating Institute

 :

Accesses

 :

- Accesses

InCites™

 :

Altmetrics

 :

[CLARIVATE ANALYTICS], [WEB OF SCIENCE], [HIGHLY CITED PAPER & CUP LOGO] and [HOT PAPER & FIRE LOGO] are trademarks of Clarivate Analytics, and/or its affiliated company or companies, and used herein by permission and/or license.

Return to the previous page